Progression: The Terminal Stage in Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Terminal differentiation-resistant epidermal cells in mice undergoing two-stage carcinogenesis.
We have used an in vivo-in vitro approach to investigate the cellular aspects of two-stage skin carcinogenesis. Female SENCAR mice initiated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were promoted twice weekly with 12-O-tetradecanoylphorbol-13-acetate (TPA). Epidermal cultures from untreated or TPA-treated mice had few focus-forming cells resistant to calcium-induced terminal differentia...
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Carcinogen treatment of normal mouse epidermal cells causes some cells, if cultured under the appropriate conditions, to continue to proliferate instead of terminally differentiate, forming foci at 37 degrees C in medium with a calcium level above 0.1 mM. We have examined these Calcium (Ca)-resistant cells formed in the skin of SENCAR mice after treatment with the carcinogen initiator 7,12-dime...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1989
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1989.tb01683.x